Adenosine | 58-61-7

Adenosine, oo ah nucleoside ka kooban adenine iyo ribose, waxay leedahay codsiyo dhowr ah oo muhiim ah oo ku saabsan daawada iyo physiology sababtoo ah saameynta jireed ee hababka kala duwan ee jirka.

Daawooyinka Wadnaha:

Qalabka ogaanshaha: Adenosine waxaa loo isticmaalaa sidii wakiilka walaaca farmasiga inta lagu jiro tijaabooyinka cadaadiska wadnaha, sida sawir-qaadista wadnaha myocardial. Waxay ka caawisaa in la qiimeeyo cudurka halbowlaha halbowlaha iyada oo kicinaysa xididdada xididdada dhiigga, iyada oo la jaanqaadaysa saameynta jimicsiga jirka.

Daawaynta Tachycardia Supraventricular (SVT): Adenosine waa dawada safka koowaad ee joojinta qaybaha SVT. Waxay u shaqeysaa iyadoo hoos u dhigaysa socodka marinka loo yaqaan 'atrioventricular node', iyada oo carqaladeyneysa dariiqyada soo laabashada ee mas'uul ka ah SVT.

Neerfaha:

Xakamaynta suuxdinta: Adenosine waa anticonvulsant endogenous ee maskaxda. Dib-u-habaynta adenosine reseptors waxay yeelan kartaa saameyn liddi ku ah suuxdinta, iyo wakiilada sii daaya adenosine ayaa loo baarayaa inay yihiin daweyn suurtagal ah oo suuxdin ah.

Ilaalinta Neuroprotection: Adenosine reseptors waxay door ka ciyaaraan ilaalinta neerfayaasha dhaawaca ischemic iyo walbahaarka oksaydhka. Cilmi-baaristu waxay sahamisaa kartida adenosine sida wakiilka neuroprotective ee istaroogga iyo cudurrada neurodegenerative sida Parkinson's iyo Alzheimers.

Daawooyinka Neefsashada:

Bronchodilator: Adenosine wuxuu u shaqeeyaa sida bronchodilator waxaana loo isticmaalaa baaritaanka bronchoprovocation si loo ogaado neefta. Waxay kicisaa xanuunka bronchoconstriction ee shakhsiyaadka qaba neefta, caawinta in la aqoonsado hyperreactivity marin-haweedka.

Astaamaha Antiarrhythmic:

Adenosine wuxuu xakameyn karaa noocyada qaar ee arrhythmias isagoo beddela dhaqdhaqaaqa korantada ee wadnaha, gaar ahaan atria iyo qanjidhada atrioventricular. Nolosheeda kala badhkeeda gaaban waxay xaddidaysaa saamaynta nidaamka.

Qalabka Cilmi-baarista:

Adenosine iyo analogs-keeda ayaa si weyn loogu isticmaalaa cilmi-baarista si loo barto doorka adenosine-ka receptors ee hababka jireed iyo cudurada kala duwan. Waxay ka caawiyaan qeexidda hawlaha adenosine ee neurotransmission, ka jawaab celinta difaaca, caabuqa, iyo nidaaminta wadnaha iyo xididdada.

Codsiyada Daawaynta ee suurtogalka ah:

Daawooyinka ku saleysan Adenosine ayaa lagu baarayaa codsiyada daweynta ee suurtagalka ah ee xaaladaha sida kansarka, dhaawaca ischemic, maaraynta xanuunka, iyo xanuunada bararka. Adenosine receptor agonists iyo antagonists ayaa ka mid ah xeryahooda daraasadda lagu wado.