Conotoxin | 129129-65-3
Sharaxaada Alaabta:
Conotoxins waa koox kala duwan oo ah sunta peptide-ka yar ee ay soo saaraan snails cone (genus Conus). Shimbirahan badeedka ah waxaa laga helaa badaha kulaala iyo kuwa hoose waxaana lagu yaqaanaa habka ugaarsiga gaarka ah. Snails cone waxay isticmaashaa sun si ay u dhaqaajiso ugaadha, taas oo ugu horrayn ka kooban noolaha kale ee badda sida kalluunka iyo gooryaanka.
Conotoxins waxaa laga helaa sunta snails cone waxayna u adeegtaa ujeedooyin kala duwan, sida hoos u dhigista ugaadhsiga iyo ka hortagga ugaadhsiga. peptides-ka ku jira conotoxins-ku waxay leeyihiin hawlo fara badan oo farmaajo ah waxayna la falgali karaan soo-qabayaal gaar ah iyo kanaalada ion ee habdhiska dareenka. Sababo la xiriira gaarkooda sare ee bartilmaameedyada qaarkood, conotoxins ayaa soo jiitay dareenka cilmi-baarayaasha isticmaalka suurtagalka ah ee daawada iyo horumarinta daroogada.
Conotoxins waxaa loo kala saaraa qoysas dhowr ah iyadoo lagu saleynayo qaab-dhismeedkooda iyo soo-dhoweeyaha bartilmaameedka ah ee ay la falgalaan. Qoysaska qaar waxaa ka mid ah:
A-conotoxins: Bartilmaameedka nicotinic acetylcholine reseptors.
M-conotoxins: xannibi kanaalada soodhiyamka ee danabku ka kooban yahay.
O-conotoxins: La falgal kanaalada kaalshiyamka ah ee danabka leh.
T-conotoxins: Bartilmaameedka kanaalada potassium-ku xiran yahay.
Suntan ayaa muujisay ballan qaadka horumarinta dawooyinka cusub ee maaraynta xanuunka, xanuunka neerfaha, iyo xaaladaha kale ee caafimaad. Saynis yahanadu waxay si gaar ah u xiiseeyaan awooda ay u leeyihiin inay si door ah wax uga bedelaan reseptors gaar ah, taasoo ka dhigaysa inay qiimo u yeelan karaan qaabaynta dawooyin la beegsaday oo waxtar leh.
Xidhmada:25KG/BAG ama sida aad codsato.
Kaydinta:Ku kaydi meel hawo leh oo qallalan.
FulintaHeerka:Heerka Caalamiga ah.
