Flubendazole | 31430-15-6
Sharaxaada Alaabta:
Flubenzimidazole waa cayayaan benzimidazole synthetic taas oo joojin karta nuugista nematode iyo isu geynta microtubules-ka unugyada gudaha.
Waxay yeelan kartaa xidhiidh adag oo leh tubulin (protein subunit dimer ee microtubules) waxayna ka hortagtaa microtubules inay polymerization unugyada nuugista (sida unugyada nuugista unugyada mindhicirka ee nematodes). Waxaa lagu xaqiijin karaa marka la waayo (fiican) microtubules cytoplasmic iyo ururinta walxaha sirta ah ee cytoplasmka sababtoo ah gudbinta xanniban.
Natiijo ahaan, dahaarka xuubka unugga ayaa noqda mid khafiif ah, awoodda dheefshiidka iyo nuugista nafaqooyinka ayaa daciifa. Sababtoo ah ururinta walxaha qarsoon (hydrolases iyo proteolytic enzymes), unugyadu waxay maraan lysis iyo hoos u dhac, ugu dambeyntiina waxay keenaan dhimasho dulin ah.
Codsiga:
Flubenzimidazole waa cayayaan ka celisa ballaaran oo si wax ku ool ah u daweyn kara dulinnada eeyaha, sida gooryaanka caloosha iyo mindhicirka, hookworms, iyo whipworms; Isla mar ahaantaana, waxay sidoo kale daweyn kartaa dulin badan oo caloosha ah oo ku jira doofaarka iyo digaaga, sida Ascaris suum, Hyostrongylus rubidus, Oesophagostomum dentatum, Trichuris suis, Metastrongylus apri, iwm.
Flubenzimidazole ma dili karto dadka waaweyn oo keliya, laakiin sidoo kale ukunta.
