Fludarabine | 21679-14-1

Fludarabine waa daawaynta kiimikaad ee ugu horreyn loo isticmaalo daawaynta noocyada kansarrada qaarkood, gaar ahaan cudurrada dhiig-baxa. Halkan waxaa ah dulmar:

Farsamaynta Falka: Fludarabine waa analooga nucleoside kaaso farageliya isku-dhafka DNA iyo RNA. Waxay joojisaa DNA-da polymerase, DNA primase, iyo enzymes DNA ligase, taasoo horseedaysa jebinta DNA-da iyo joojinta hababka dayactirka DNA. Khalkhalkan DNA-ga isku-dhafka ah wuxuu ugu dambeyntii keenaa apoptosis (dhimashada unugyada qorshaysan) ee unugyada si degdeg ah u qaybsan, oo ay ku jiraan unugyada kansarka.

Tilmaamaha: Fludarabine waxaa badanaa loo isticmaalaa daaweynta leukemia lymphocytic chronic (CLL), iyo sidoo kale cudurrada kale ee hematological sida lymphoma non-Hodgkin indolent iyo mantle cell lymphoma. Waxa kale oo loo isticmaali karaa xaalado gaar ah oo ah cudurka leukemia myeloid ba'an (AML).

Maamulka: Fludarabine waxaa sida caadiga ah lagu maamulaa xididada (IV) goob caafimaad, inkastoo laga yaabo in sidoo kale afka laga bixiyo xaaladaha qaarkood. Qiyaasta iyo jadwalka maamulku waxay ku xidhan yihiin kansarka gaarka ah ee la daweeyey, iyo sidoo kale caafimaadka guud ee bukaanka iyo jawaabta daaweynta.

Saamaynnada xun: Dhibaatooyinka caadiga ah ee fludarabine waxaa ka mid ah xakamaynta dhuuxa lafta (oo keenta neutropenia, dhiig-yaraan, iyo thrombocytopenia), lallabbo, matag, shuban, qandho, daal, iyo korodhka u nuglaanshaha caabuqyada. Waxa kale oo ay keeni kartaa waxyeelo aad u daran sida neurotoxicity, hepatotoxicity, iyo sumoobo sambabada xaaladaha qaarkood.

Taxadir: Fludarabine waa ka mamnuuc bukaanada qaba xakameynta dhuuxa lafta ama shaqada kelyaha oo daciif ah. Waa in si taxadar leh loogu isticmaalo bukaanada qaba beerka ama kelyaha ee hore u jiray, iyo sidoo kale haweenka uurka leh ama naaska nuujinaya sababtoo ah suurtagalnimada waxyeellada uurjiifka ama ilmaha.

Isdhexgalka Daroogada: Fludarabine waxaa laga yaabaa inay la falgasho daawooyinka kale, gaar ahaan kuwa saameeya shaqada dhuuxa lafta ama shaqada kelyaha. Aad bay muhiim u tahay bixiyeyaasha daryeelka caafimaadku inay si taxadar leh u eegaan liiska daawaynta bukaanka oo ay ula socdaan isdhexgalka daroogada ee suurtogalka ah.

Korjoogteynta: Kormeerka joogtada ah ee tirooyinka dhiigga iyo shaqada kelyaha ayaa muhiim ah inta lagu jiro daawaynta fludarabine si loo qiimeeyo calaamadaha xakamaynta dhuuxa lafta ama saameynaha kale ee xun. Dib-u-habaynta qiyaasta ayaa laga yaabaa inay lagama maarmaan noqoto iyadoo lagu saleynayo cabbirrada kormeerka.