L-Tyrosine | 60-18-4
Sharaxaada Alaabta
Tyrosine (oo loo soo gaabiyo Tyr ama Y) ama 4-hydroxyphenylalanine, waa mid ka mid ah 22 amino acids oo ay unugyadu isticmaalaan si ay u abuuraan borotiinada. Codansare UAC iyo UAU. Waa amino acid aan muhiim ahayn oo leh koox dhinac ah. Ereyga "tyrosine" wuxuu ka yimid Giriigga tyros, oo macneheedu yahay farmaajo, sida markii ugu horreysay la helay 1846-kii farmashiistaha Jarmalka Justus von Liebig ee borotiinka ka soo farmaajada. Waxaa loo yaqaan tyrosyl marka loo tixraaco sida silsilada dhinaca kooxda. Saamaynta niyadda ayaa aad uga muuqata bini'aadamka oo ay ku jiraan xaalado walaac leh.
Marka laga reebo inay tahay amino acid proteinogenic, tyrosine waxay leedahay door gaar ah iyadoo loo eegayo shaqeynta phenol. Waxay ku dhacdaa borotiinno ka mid ah hababka gudbinta calaamadaha. Waxay u shaqeysaa sidii qaataha kooxaha fosfooraska ee lagu wareejiyo habka borotiinka (waxa loogu yeero tyrosine kinases). Phosphorylation ee kooxda hydroxyl waxay beddeshaa dhaqdhaqaaqa borotiinka la beegsanayo.
Haraaga tyrosine sidoo kale wuxuu door muhiim ah ka ciyaaraa photosynthesis. chloroplasts (photosystem II), waxay u shaqeysaa sidii ku deeqaha anelectron ee dhimista chlorophyll oksaydheysan. Geedi socodkan, waxa ay maraysaa deprotonation ee kooxdeeda phenolic OH. Xagjirkan waxa markii dambe hoos u dhigay nidaamka sawir-qaadista ee II oo ay hoos u dhigeen afarta qaybood ee manganese xudunta u ah.
Tiro cilmi-baaris ah ayaa lagu ogaaday in tyrosine ay faa'iido leedahay inta lagu jiro xaaladaha walaaca, qabowga, daalka, luminta qofka aad jeceshahay sida dhimashada ama furiinka, shaqo dheeraad ah iyo hurdo la'aan, hoos u dhigista heerarka hoormoonka walbahaarka, hoos u dhigista miisaanka hoos u dhaca walaaca. tijaabooyinka xayawaanka, hagaajinta garashada iyo waxqabadka jireed ee lagu arkay aadanaha; si kastaba ha ahaatee, sababtoo ah tyrosine hydroxylase waa enzyme xad-dhaaf ah, saamayntu aad uga yar yihiin kuwa L-DOPA.
Tyrosine uma eka inay wax saameyn ah ku leedahay niyadda, garashada ama waxqabadka jirka ee xaaladaha caadiga ah. Qiyaasta maalinlaha ah ee baaritaanka kiliinikada ee lagu taageeray suugaanta waxay ku saabsan tahay 100 mg / kg qofka weyn, taas oo ah qiyaastii 6.8 garaam oo 150 rodol ah. Qiyaasta caadiga ah waxay gaartaa 500-1500 mg maalintii (qiyaas ay soo jeediyaan warshadeeyayaasha intooda badan; inta badan waxay u dhigantaa 1-3 kaabsal oo tyrosine saafi ah). Laguma talinayo in ka badan 12000 mg (12 g) maalintii.
Tilmaamid
| Walxaha | Heerka | Natiijooyinka tijaabada |
| Wareeg gaar ah[a]ᴅ²⁰ | -9.8° ilaa-11.2° | -10.4° |
| Chloride (CI) | In aan ka badnayn 0.05% | 20.05% |
| Sulfate (SO₄) | In aan ka badnayn 0.04% | 20.04% |
| Birta(Fe) | In aan ka badnayn 0.003% | 20.003% |
| Biraha culus | In aan ka badnayn 0.00015% | 20.00015% |
| Luminta qalajinta | In aan ka badnayn 0.3% | 20.3% |
| Hadhaaga dabka | In aan ka badnayn 0.4% | 20.4% |
| Qiimayn | 98.5% -101.5% | 99.3% |
| Gabagabo | Waafaqsan heerka USP32 | |
