Mitomycin C | 50-07-7

Mitomycin C waa daawaynta kiimikaad ee loo isticmaalo daawaynta noocyada kala duwan ee kansarka. Waxay ka tirsan tahay daawoyinka loo yaqaan antineoplastic antibiyootiga. Mitomycin C wuxuu u shaqeeyaa isagoo farageliya korriinka iyo taranka unugyada kansarka, ugu dambeyntiina keena dhimashadooda.

Waa kuwan qaar ka mid ah qodobbada muhiimka ah ee ku saabsan Mitomycin C:

Mechanism of Action: Mitomycin C waxay u shaqeysaa iyada oo ku xidhan DNA-da oo joojisa soo-celinteeda. Waxay isku xirtaa xargaha DNA-da, taas oo ka hortagaysa inay kala tagaan inta lagu jiro qaybta unugga, taas oo ugu dambeyntii keenta dhimashada unugyada.

Tilmaamaha: Mitomycin C waxaa caadi ahaan loo isticmaalaa in lagu daweeyo noocyada kansarka qaarkood, oo ay ku jiraan kansarka caloosha (gastric), kansarka ganaca, kansarka futada, kansarka kaadiheysta, iyo qaar ka mid ah noocyada kansarka sanbabada. Waxa kale oo laga yaabaa in lagu daro dawooyinka kale ee kiimoterabiga ama daaweynta shucaaca.

Maamulka: Mitomycin C waxaa sida caadiga ah xididka ku bixiya xirfadle daryeel caafimaad goob caafimaad sida isbitaal ama xarun faleebo.

Saamaynnada Dhinacyada ah: Dhibaatooyinka caadiga ah ee Mitomycin C waxaa ka mid noqon kara lallabbo, matag, shuban, daal, iyo hoos u dhaca tirada unugyada dhiigga (anemia, leukopenia, trombocytopenia). Waxa kale oo laga yaabaa inay keento waxyeelo ka sii daran sida xakamaynta dhuuxa lafta, sunta kelyaha, iyo sunta sambabada.

Taxadir: Sababo la xiriira suurtagalnimada sunta, Mitomycin C waa in si taxadar leh loo isticmaalo, gaar ahaan bukaanka qaba dhibaatooyinka kelyaha ama beerka ee hore u jiray. Bukaanka qaata Mitomycin C waa in si dhow loola socdo calaamadaha waxyeellada xun.

Isticmaalka Daaweynta Kansarka: Mitomycin C waxaa badanaa loo isticmaalaa qayb ka mid ah hababka daaweynta kemotherabi ee isku dhafan ama iyadoo lala kaashanayo daawaynta kale ee kansarka si loo hagaajiyo natiijooyinka bukaannada qaba noocyada kala duwan ee kansarka.