Tacrolimus | 104987-11-3

Tacrolimus, oo sidoo kale loo yaqaano magaceeda ganacsiga Prograf iyo kuwa kale, waa daawo difaac difaac ah oo awood leh oo inta badan loo isticmaalo beerista xubnaha si looga hortago diidmada.

Mechanism of Action: Tacrolimus wuxuu u shaqeeyaa isagoo xakameynaya calcineurin, fosfatase borotiin ah oo door muhiim ah ka ciyaara firfircoonida T-lymphocytes, kuwaas oo ah unugyada difaaca ee ku lug leh diidmada tallaalka. Iyadoo la xakameynayo calcineurin, tacrolimus waxay xannibaysaa soo saarista cytokines pro-inflammatory waxayna ka hortagtaa firfircoonida unugyada T-yada, taas oo xakameynaysa jawaabta difaaca ee xubinta la tallaalay.

Tilmaamaha: Tacrolimus waxaa loogu talagalay ka-hortagga diidmada xubnaha ee bukaannada qaata beerka allogeneic, kelyaha, ama tallaalka wadnaha. Inta badan waxaa lagu daraa wakiilada kale ee difaaca jirka sida corticosteroids iyo mycophenolate mofetil.

Maamulka: Tacrolimus waxaa sida caadiga ah lagu maamulaa afka oo ah qaab kaabsal ama xal afka ah. Waxa kale oo laga yaabaa in xididka la iska siiyo xaalado caafimaad oo gaar ah, sida xilliga tallaalka ka dib.

Korjoogteynta: Sababtoo ah tusmooyinka daweynta cidhiidhiga ah iyo kala duwanaanshiyaha nuugista, tacrolimus waxay u baahan tahay kormeer taxadar leh oo ku saabsan heerarka dhiigga si loo hubiyo waxtarka daaweynta iyada oo la yareeyo khatarta sunta. Kormeerka daawada daawaynta waxay ku lug leedahay cabbirka joogtada ah ee heerarka dhiigga tacrolimus iyo hagaajinta qiyaasta ku salaysan heerarkan.

Saamaynnada xun: Dhibaatooyinka caadiga ah ee tacrolimus waxaa ka mid ah nephrotoxicity, neurotoxicity, hypertension, hyperglycemia, khalkhalka caloosha iyo mindhicirka, iyo korodhka u nuglaanshaha caabuqyada. Isticmaalka muddada dheer ee tacrolimus waxa kale oo laga yaabaa inay kordhiso khatarta ah inay ku dhacaan cudurrada qaarkood, gaar ahaan kansarka maqaarka iyo lymphoma.

Isdhexgalka daroogada: Tacrolimus waxaa ugu horreyntii metabolized by nidaamka cytochrome P450 enzyme, gaar ahaan CYP3A4 iyo CYP3A5. Sidaa darteed, daawooyinka keena ama joojiya enzymes-yadan waxay saameyn karaan heerarka tacrolimus ee jirka, taas oo keeni karta guuldarada daaweynta ama sunta.

Tixgalin gaar ah: Qiyaasta Tacrolimus waxay u baahan tahay shaqsiyaynta oo ku salaysan arrimo ay ka mid yihiin da'da bukaanka, miisaanka jidhka, shaqada kelyaha, daawooyinka isku dhafan, iyo joogitaanka cudurrada wadajirka ah. Korjoogteynta dhow iyo la socodka joogtada ah ee bixiyeyaasha daryeelka caafimaadka ayaa muhiim u ah wanaajinta daaweynta iyo yaraynta saameynta xun.