L-Carnitine | 541-15-1
Sharaxaada Alaabta
L-carnitine, mararka qaarkood loo yaqaan si fudud carnitine, waa nafaqo laga soo saaray amino acids methionine iyo lysine ee beerka iyo kelyaha waxaana lagu kaydiyaa maskaxda, wadnaha, unugyada muruqyada, iyo shahwada. Dadka intooda badan waxay soo saaraan xaddi ku filan oo nafaqeeyayaalkan ah si ay u ahaato mid caafimaad qabta. Dhibaatooyinka caafimaad qaarkood, si kastaba ha ahaatee, waxay ka hortagi karaan biosynthesis ee carnitine ama waxay joojin karaan qaybinta unugyada unugyada, sida claudication dhexdhexaad ah, cudurada wadnaha, iyo cudurada hiddaha qaarkood. Daawooyinka qaarkood waxay sidoo kale si xun u saameeyaan dheef-shiid kiimikaadka carnitine ee jirka. Shaqada aasaasiga ah ee L-carnitine waa in loo beddelo lipids, ama dufanka, oo loo beddelo tamarta tamarta.
Gaar ahaan, doorkeedu waa in ay u guurto asiidh dufanka ah mitochondria ee unugyada eukaryotic ee ku dhex nool xuubka difaaca ee ku wareegsan unugyada. Halkan, asiidhyada dufanka leh waxay maraan beta oxidation waxayna burburaan si ay u sameeyaan acetate. Dhacdadani waa waxa ka bilaabma wareegga Krebs, taxane falcelin bayooloji ah oo adag kuwaas oo lagama maarmaan u ah bixinta tamarta unug kasta oo jirka ah.L-carnitine ayaa sidoo kale door ka ciyaara ilaalinta cufnaanta lafaha. Nasiib darro, nafaqeyntani waxay noqotaa mid aan ku urursanayn lafaha oo ay weheliso osteocalcin, borotiinka uu soo daayo osteoblasts kaas oo ku lug leh macdanta lafaha. Dhab ahaantii, cilladahan ayaa ah arrimaha ugu muhiimsan ee gacan ka geysta lafo-beelka haweenka postmenopausal. Daraasaduhu waxay muujiyeen in xaaladdan laga yaabo in lagu beddelo dheellitirka L-carnitine, taas oo kordhisa heerarka la heli karo ee osteocalcin.
Arrimaha kale ee daaweynta L-carnitine laga yaabo inay wax ka qabato waxaa ka mid ah isticmaalka gulukooska ee la xoojiyey ee sonkorowga, calaamadaha hoos u dhaca ee la xidhiidha daalka dabadheeraad ah, iyo hagaajinta nidaamka tayroodh ee dadka qaba hyperthyroidism. Waxa kale oo jira caddayn muujinaysa in propionyl-L-carnitine laga yaabo inay gacan ka geysato hagaajinta cillad-darrada ragga, iyo sidoo kale kor u qaadida waxtarka sidenafil, daawada lagu iibiyo iyada oo loo marayo calaamadda Viagra. Intaa waxaa dheer, cilmi-baaris ayaa muujisay in nafaqeyntani ay wanaajiso tirada shahwada iyo dhaqdhaqaaqa.
Tilmaamid
| WAXYAABAHA | Tilmaamaha |
| Muuqashada | Crystals cad ama budada crystalline |
| Aqoonsiga | Habka Kiimikada ama IR ama HPLC |
| Muuqashada Xalka | Cad oo aan midab lahayn |
| Wareeg gaar ah | -29°∼-32° |
| PH | 5.5-9.5 |
| Waxa ku jira biyaha =< % | 1 |
| Qiimayn % | 97.0 ~ 103.0 |
| Hadhaaga dabka =< % | 0.1 |
| Hadhaaga ethanol = < % | 0.5 |
| Biraha culus = < PPM | 10 |
| Arsenic = < PPM | 1 |
| Chloride = < % | 0.4 |
| hogaanka =< PPM | 3 |
| Meerkuri = < PPM | 0.1 |
| Cadmium = < PPM | 1 |
| Wadarta tirada saxanada = | 1000cfu/g |
| Khamiir & Caar = | 100cfu/g |
| E. Coli | xun |
| Salmonella | xun |
